Soluble CD163 is a biomarker for macrophage activity, inflammation, CVD and MS.
sCD163 is very useful as a biomarker of macrophage activation in various inflammatory diseases, such as macrophage activation syndrome, sepsis, and liver disease. (Møller HJ. Soluble CD163. Scand J Clin Lab Invest. 2012 Feb;72(1):1-13)
Citations for Human CD163 ELISA Kit SK00694-01:
PLoS One. 2014; 9(6): e98989. Published online 2014 Jun 4.
Eleanor M. P. Wilson., et al. Monocyte-Activation Phenotypes Are Associated With Biomarkers of Inflammation and Coagulation in Chronic HIV Infection. The Journal of Infectious Diseases, 2014(210)Pages 1396–1406
Min D, et al. Monocyte CD163 is altered in association with diabetic complications: possible protective role. J Leukoc Biol. 2016 Dec;100(6):1375-1383
A. CINKAJZLOVÁ, et al. An Alternatively Activated Macrophage Marker CD163 in Severely Obese Patients: the Influence of Very Low-Calorie Diet and Bariatric Surgery. Physiol. Res. 66: 641-652, 2017
Sun, Houchao et al. “Circulating Soluble CD163: A Potential Predictor for the Functional Outcome of Acute Ischemic Stroke.” Frontiers in neurology vol. 12 740420. 14 Dec. 2021, doi:10.3389/fneur.2021.740420
Nielsen MC, et al. Extracellular vesicle-associated soluble CD163 and CD206 in patients with acute and chronic inflammatory liver disease. Scand J Gastroenterol. 2020 May;55(5):588-596.
Size: 96 T
Standard Range: 78-5000 pg/mL
Sensitivity: 30 pg/mL
Sample Type: serum, EDTA plasma
Dilution Factor: 200
Sample Volume: 100 uL
Intra-CV: 4-6%
Inter-CV: 8-12%
Protocol: PDF
Citations for Human CD163 ELISA Kit SK00694-01
References related to MS:
Semnani-Azad Z, Connelly PW, Johnston LW, et al. The Macrophage Activation Marker Soluble CD163 is Longitudinally Associated With Insulin Sensitivity and β-cell Function. J Clin Endocrinol Metab. 2020;105(3):e285-e294. doi:10.1210/clinem/dgz166
Sherman KE, et al. Soluble CD163 Identifies Those at Risk for Increased Hepatic Inflammation & Fibrosis. Open Forum Infect Dis. 2021 Apr 22;8(6):ofab203. doi: 10.1093/ofid/ofab203.