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- Parvalbumin (PV) are inhibitory neurons in the brain that control network activity, synchrony, and plasticity, playing crucial roles in cognitive functions like learning and memory, and in maintaining the brain's excitation-inhibition balance. Dysfunction or injury to these PV interneurons is linked to several neurological and psychiatric conditions. Maintaining the health of PV neurons is a key area of research for developing treatments for these conditions.
- Parvalbumin plays a key role in both muscle and brain metabolism by acting as a calcium buffer, which affects muscle relaxation and nerve cell activity. In muscle, it accelerates muscle relaxation, while in the brain, its function in parvalbumin-positive interneurons (PV-INs) is linked to regulating neuronal excitability and energy metabolism. Furthermore, parvalbumin is involved in metabolic diseases, with reduced circulating parvalbumin associated with increased obesity and exercise benefits, and oxidative stress impacting PV-INs in conditions like neurodegenerative disorders.
- Assay Range: 250 ~ 16000 pg/mL
- Sensitivity: 50 pg/mL
- Calibration: rh Parvalbumin Recombinant
- Specificity: human
- Sample Type: Serum, Plasma
- Size: 96 T, 192 T
- Price: contact with us
- Anti human PVALB Antibodies Pair validated on western blot.
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Features
Size: 96 T Standard Range: 250-16000 pg/ml Sensitivity: 50 pg/ml Sample Type: serum, plasma, Sample Requires: Specificity: human parvalbumin Intra-CV: 2-5% Inter-CV: 4-7% Protocol: PDF
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