C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight

CTRP4 is a unique member of the C1q family, possessing two tandem globular C1q domains; its physiological function is poorly defined. Here, we show that CTRP4 is an evolutionarily conserved ~34 kDa secretory protein expressed in the brain. In human, mouse, and zebrafish brain, CTRP4expression begins early in development and is widespread in the central nervous system. Neurons, but not astrocytes, express and secrete CTRP4, and secreted proteins form higher-order oligomeric complexes. CTRP4 is also produced by peripheral tissues and circulates in blood; its serum levels are increased in leptin-deficient obese (ob/ob) mice. Functional studies suggest that CTRP4 acts centrally to modulate energy metabolism. Re-feeding following an overnight fast induced the expression of CTRP4 in the hypothalamus. Central administration of recombinant protein suppressed food intake and altered whole-body energy balance in both chow-fed and high-fat diet-fed mice. Suppression of food intake by CTRP4 is correlated with decreased expression of orexigenic neuropeptide (Npy and Agrp) genes in the hypothalamus. These results establish CTRP4 as a novel nutrient-responsive central regulator of food intake and energy balance.

Byerly MS et al. J Biol Chem. 2013 Dec 23. [Epub ahead of print]

Human CTRP4 ELISA Kit

Code No.: SK00090-06

Size: 96 T

Price: $

Standard range:1.56-100 ng/ml

Sensitivity: 300 pg/ml

Sample Type: serum, plasma

sample require: 100 µL per well

Intra-CV: 4-6%

Inter-CV: 8-10%

Data Sheet: PDF

Mouse /Rat CTRP4 ELISA Kit

Code No.: SK00090-07

Size: 96 T

Price: $

Standard range: 1.56-100 ng/ml

Sensitivity: 390 pg/ml

Sample Type: serum, plasma

sample require: 100 µL per well

Intra-CV: 4-6%

Inter-CV: 8-10%

Data Sheet: PDF

Anti-Human CTRP4 Monoclonal Antibody

Code No.: A00090-07-100

Size: 100 µg

Clone: 1F1D4F6

Antibody Type: IgG

Purification: Protein G

Antigen: CTRP4 (Human) (25-162)

Applications: WB (1-2 µg/ml), ELISA

Data Sheet: PDF

Validated Antibody by WB and ELISA

Anti-Human CTRP4 (25-162 ) IgG

Code No.: A00090-02-100

Size: 100 µg

Host: Rabbit

Antigen: human CTRP4 (25-162) Rec.

Ab Type: Polyclonal IgG

Purification: Protein A

Applications: E, IHC (2 µg/ml)

Data Sheet: PDF

Validated Antibody by IHC and ELISA

Anti-Human CTRP4 Monoclonal Antibody

Code No.: A00090-09-100

Size: 50 µg

Clone: 2B1C6H11

Antibody Type: IgG

Purification: Protein G

Antigen: CTRP4 (Human) globular form

Applications: WB (1-2 µg/ml), ELISA

Data Sheet: PDF

Validated Antibody by WB and ELISA

Anti-Human CTRP4 Monoclonal Antibody

Code No.: A00090-04-100

Size: 100 µg

Clone: F11C12

Antibody Type: IgG

Purification: Protein G

Antigen: CTRP4 (Human) (172-317)

Applications: WB (1-2 µg/ml), ELISA

Data Sheet: PDF

Validated Antibody by WB and ELISA

Anti-Human CTRP4 Monoclonal Antibody

Code No.: A00090-05-100

Size: 100 µg

Clone: C1C12

Antibody Type: IgG

Purification: Protein G

Antigen: CTRP4 (Human) (172-317)

Applications: WB (1-2 µg/ml), ELISA

Data Sheet: PDF

Validated Antibody by WB and ELISA

Human CTRP4 Globular Form II (172-317) Recombinant

Code No.: 00090-01-100

Size: 100 µg

Protein ID: Q9BXJ3

Gene ID: 114900

MW:19.9 KD

Tag: His Tag on N-Terminus

Expressed: E. Coli

Purity: 90%

Data Sheet: PDF

Human CTRP4 Globular Form I (25-162) Recombinant

Code No.: 00090-02-100

Size: 100 µg

Protein ID: Q9BXJ3

Gene ID: 114900

MW:18.7 KD

Tag: His Tag on N-Terminus

Expressed: E. Coli

Purity: 90%

Data Sheet: PDF