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- Neprilysin /CD10 is a soluble biomarker for Heart Failure and cardiovascular research.
- Neprilysin is an enzyme that plays a role in breaking down amyloid-beta peptides in the brain. Amyloid-beta accumulation is a hallmark of Alzheimer’s disease, so NEP’s activity is significant in preventing or slowing the progression of this neurodegenerative condition.
- NEP is an enzyme that breaks down natriuretic peptides, which are involved in blood pressure regulation and fluid balance.
- Standard Range: 15.6 ~ 1000 pg/mL
- Sensitivity: 3 pg/mL
- Calibration: rh Neprilysin-Fc Fusion (HEK293) or rh NEP (HEK293)
- Sample Type: Serum, Plasma
- Size: 96 T
Citations:- Julio Nunez et al. J Am Heart Assoc. 2017;6:e005712. DOI: 10.1161/JAHA.117.005712.
- Antoni Bayes-Genis, Jaume Barallat, et al. "Soluble Neprilysin is Predictive of Cardiovascular Death and Health Failure Hospitalization in Heart Failure Patients" Journ
- Choi, I.J., Lim, S., Hwang, Y. et al. "Soluble neprilysin and long-term clinical..." a retrospective cohort study. BMC Cardiovasc Disord 20, 360 (2020). https://doi.org/10.1186/s12872-020-01636-5
- Hwang Hyeon Seok, et al. Circulating Neprilysin Level Predicts the Risk of Cardiovascular Events in Hemodialysis Patients. Frontiers in Cardiovascular Medicine 599 (8) 2021 https://www.frontiersin.org/article/10.3389/fcvm....
New Research:
- Eunhee Kim, et al. Irisin reduces amyloid-b by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling. Neuron 111, 3619–3633, November 15, 2023
 - Neprilysin is an enzyme that plays a role in breaking down amyloid-beta peptides in the brain. Amyloid-beta accumulation is a hallmark of Alzheimer’s disease, so NEP’s activity is significant in preventing or slowing the progression of this neurodegenerative condition.
- NEP is an enzyme that breaks down natriuretic peptides, which are involved in blood pressure regulation and fluid balance.
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