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Soluble FNDC4 (Human, Mouse, Rat) Recombinant
Soluble FNDC4 (Human, Mouse, Rat,Rabbit, Bovine) Recombinant


 
Our Price: $390.00


Product Code: 00386-02-100
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Description Technical Specs
 
  • Soluble Fibronectin type III Domain-Containing Protein 4 (FNDC4) is a secreted anti-inflammatory factor, upregulated in inflammatory bowel disease.
  • The novel adipokine FNDC4 reduces lipogenesis and increases fat browning in human visceral adipocytes. (Frühbeck G, et al. FNDC4, a novel adipokine that reduces lipogenesis and promotes fat browning in human visceral adipocytes. Metabolism. 2020 Jul;108:154261)
  • FNDC4 acts as an anti-inflammatory factor
New References of FNDC4 Research:
  • Georgiadi A, et al. Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue. Nat Commun. 2021 May 20;12(1):2999
  • Daudon M, Bigot Y, Dupont J, Price CA. Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction. Reproduction. 2022 May 23;164(1):R1-R9
  • Frühbeck G, et al., Rodríguez A. FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes. Cell Mol Immunol. 2021 Oct;18(10):2457-2459.
  • FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-κB and CXCL10 Expression. Lv ZT et al. Biomed Res Int. 2018 May 30;2018:3936257.
Features
  • Code No.: 00386-02-100
    Size: 100 ug
    Protein ID: NP_073734.1
    Gene ID:NM_022823.2
    Sequence: Asp45-Thr167
    MW:15 KD (non-glycosylated)
    Tag: His Tag on N-Terminus
    Expressed: E. Coli
    Purity: 95%
    Data Sheet: PDF


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