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- Myonectin, or Complement C1q Tumor necrosis factor-Related Protein 15, is a novel myokine that links skeletal muscle to systemic lipid homeostasis.
- Size: 50ug
- Myonectin, a member of the CTRP family, is a type of myokine released by skeletal muscle cells. Although several studies have shown that myonectin is associated with lipid metabolism, the role of myonectin during adipogenesis is not known. Here, we demonstrate the role of myonectin during adipocyte differentiation of 3T3-L1 cells. We found that myonectin inhibits the adipogenesis of 3T3-L1 preadipocytes with a reduction in the expression of adipogenic transcription factors such as C/EBPα, β and PPARγ. Furthermore, we show that myonectin has an inhibitory effect on adipogenesis through the regulation of the p38 MAPK pathway and CHOP. These findings suggest that myonectin may be a novel therapeutic target for the prevention of obesity. (Tae-Jun Park et al. Myonectin inhibits adipogenesis in 3T3-L1 preadipocytes by regulating p38 MAPK pathway.BMB Reports 2021; 54(2): 124-129.)
Citations of 00393-06-100:
- Tae-Jun Park et al. Myonectin inhibits adipogenesis in 3T3-L1 preadipocytes by regulating p38 MAPK pathway.BMB Reports 2021; 54(2): 124-129.
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