Pro NGF (19-241) (Human) Recombinant

Description

Neurotrophic factors have diametrically opposing effects of the pro- and mature form through distinct receptors. (Xue Y, et al. The role of pro- and mature neurotrophins in the depression. Behav Brain Res. 2021 Apr 23)
ProNGF, the precursor of mature nerve growth factor (NGF), is the most abundant form of NGF in the brain. ProNGF and mature NGF differ significantly in their receptor interaction properties and in their bioactivity. ProNGF increases markedly in the cortex of Alzheimer's disease (AD) brains and proNGF\NGF imbalance has been postulated to play a role in neurodegeneration. (Tiveron C, et al. ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice. Cell Death Differ. 2013 Aug;20(8):1017-30.)

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