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- Lysophospholipase 1 (LYPLA1) is a ghrelin deacylation/lysophospholipid hydrolyzing enzyme.
- The Cys141 and Cys498 residues on ACE2 are S-palmitoylated by zinc finger DHHC-Type Palmitoyltransferase 3 (ZDHHC3) and de-palmitoylated by acyl protein thioesterase 1 (LYPLA1), which is critical for the membrane-targeting of ACE2 and their EV secretion. Xie F, et al.. Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 . Adv Mater. 2021 Oct 19:e2103471.
- Consistently, the protein levels of lysophospholipases A1 (LYPLA1) and phospholipase A2 group 4 A (PLA2G4) were enhanced only by live E. faecalis, which thus may have decreased the nitric oxide production in the renal medulla and elevated BP. Zhu Y, et al. . Enterococcus faecalis contributes to hypertension and renal injury in Sprague-Dawley rats by disturbing lipid metabolism. J Hypertens. 2021 Jun 1;39(6):1112-1124.
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