Alternative name: Oxidized Low-density Lipoprotein Receptor 1 (OLR1).
- High Sensitivity
- Monoclonal Antibody Pair Formulated
- Validated by WB & E
- Calibrator: human soluble LOX-1 derived from HEK293
Soluble LOX-1 is a new biomarker of cardiovascular research. Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis.
"A fermented bean flour extract downregulates LOX-1, CHOP and ICAM-1 in HMEC-1 stimulated by ox-LDL" by Morena Gabriele