Autotaxin/ENPP2 (Human) ELISA Kit
Autotaxin/ENPP2 is a biomarker for metabolic syndrome, diabetes, and liver fibrosis research.
Autotaxin (ATX) is a secreted lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA), a phospholipid growth factor acting via specific receptors (LPA1R to LPA6R) and involved in several pathologies including obesity. ATX is secreted by adipocytes and contributes to circulating LPA. ATX expression is up-regulated in obese patients and mice in relationship with insulin resistance and impaired glucose tolerance.
Rancoule C.et al.Involvement of autotaxin/lysophosphatidic acid signaling in obesity and impaired glucose homeostasis.Biochimie. 2014 Jan;96:140-3
Black KE1, et al. Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis. FASEB J. 2016 Jun;30(6):2435-50.
Mouratis MA1,et al. Autotaxin and Endotoxin-Induced Acute Lung Injury. PLoS One. 2015 Jul 21;10(7):e0133619.
This review summarizes the recent findings on the relation between ATX or LPA and liver fibrosis, the usefulness of serum ATX levels to predict the stages of liver fibrosis, and speculated roles of increased serum ATX and plasma LPA levels in liver fibrosis. Ikeda H1, Yatomi Y.Autotaxin in liver fibrosis.Clin Chim Acta. 2012 Nov 20;413(23-24):1817-21.
Autotaxin has recently emerged as an attractive target for the development of anti-cancer chemotherapeutics. In addition, Serum ATX activity was found to be enhanced in relation to hepatic fibrosis in chronic liver disease due to hepatitis virus C infection.
1: Kadekar S, et al.Exocrine pancreatic carcinogenesis and autotaxin expression. PLoS One. 2012;7(8):e43209. doi: 10.1371/journal.pone.0043209
2: Brindley DN, et al. Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy. Biochim Biophys Acta. 2013 Jan;1831(1):74-85.
3: Abu El-Asrar AM, et al. Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as
biomarkers in diabetic retinopathy. Acta Diabetol. 2013 Jun;50(3):363-71.
4: Ikeda H, Yatomi Y. Autotaxin in liver fibrosis. Clin Chim Acta. 2012 Nov 20;413(23-24):1817-21.
5: Oikonomou N, et al. Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis. Am J Respir Cell Mol Biol.2012 Nov;47(5):566-74.
6: Nakamura K,et al. Serum autotaxin is not a useful biomarker for ovarian cancer. Lipids. 2012 Sep;47(9):927-30.
7: Wood NJ. Liver: Potential of autotaxin as a diagnostic marker and therapeutic target for itch of cholestasis. Nat Rev Gastroenterol Hepatol. 2012 May 1;9(6):303.
8: Kremer AE, et al. Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions. Hepatology. 2012 Oct;56(4):1391-400
9: Houben AJ, Moolenaar WH. Autotaxin and LPA receptor signaling in cancer.
Cancer Metastasis Rev. 2011 Dec;30(3-4):557-65.
10: Dohi T, et al. Increased circulating plasma lysophosphatidic acid in patients with acute coronary syndrome. Clin Chim Acta. 2012 Jan 18;413(1-2):207-12.
11: Moolenaar WH, Perrakis A. Insights into autotaxin: how to produce and present
a lipid mediator. Nat Rev Mol Cell Biol. 2011 Sep 14;12(10):674-9.
12: Masuda A, et al. Serum autotaxin measurements in pregnant women: application for the differentiation of normal pregnancy and pregnancy-induced hypertension. Clin Chim Acta. 2011 Oct 9;412(21-22):1944-50.
Size: 96 T
Standard Range: 0.5-32 ng/ml
Sensitivity: 100 pg/ml
Sample Type: serum, plasma
Dilution Factor: 40 for plasma and serum
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